Fastbreak: a tool for analysis and visualization of structural variations in genomic data
1 Institute for System Biology, 401 Terry Avenue North, Seattle, WA, 98109-5234, USA
2 Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands
EURASIP Journal on Bioinformatics and Systems Biology 2012, 2012:15 doi:10.1186/1687-4153-2012-15Published: 9 October 2012
Genomic studies are now being undertaken on thousands of samples requiring new computational tools that can rapidly analyze data to identify clinically important features. Inferring structural variations in cancer genomes from mate-paired reads is a combinatorially difficult problem. We introduce Fastbreak, a fast and scalable toolkit that enables the analysis and visualization of large amounts of data from projects such as The Cancer Genome Atlas.