Table 1 |
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|
The results of optimization with minimum score for Tyson model. |
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|
Parameter |
Nominal value |
Estimation of the proposed cost function |
Estimation of the LS cost function |
|
|
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|
vm |
1 |
1.1372 |
0.9472 |
|
km |
0.1 |
0.1049 |
0.1097 |
|
vp |
0.5 |
0.4668 |
0.4740 |
|
kp1 |
10 |
15.88 |
21.48 |
|
kp2 |
0.03 |
0.0936 |
0.0927 |
|
kp3 |
0.1 |
0.0766 |
0.0615 |
|
Keq |
200 |
692.64 |
922.16 |
|
Pcrit |
0.1 |
0.1076 |
0.1477 |
|
Jp |
0.05 |
0.0511 |
0.0738 |
|
Score |
0.1378 |
0.1084 |
0.2441 |
|
|
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|
The values of kinetic parameters with minimum score derived from optimization using the proposed cost function and the LS cost function for the Tyson model. The bold values are the ones that are estimated incorrectly (error more than 10%). The score values are calculated based on (11) |
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|
Nabavi and Williams EURASIP Journal on Bioinformatics and Systems Biology 2012 2012:3 doi:10.1186/1687-4153-2012-3 |
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